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What Is Cyspera?

Cyspera is is a pigment correcting system that is used to treat hyperpigmentation disorders and photo damage, both acute and chronic. It is the first, original, and best studied cysteamine product available with the highest percentage of active ingredient (7%) on the market. It is the only cysteamine product to have published clinical trials proving the efficacy of the formulation. Cyspera contains a molecule called cysteamine, which works by safely decreasing the amount of melanin produced in the skin without causing damage to the melanin-producing cells. It is non-cytotoxic, non-carcinogenic and non-mutagenic.

This cream is manufactured by Scientis Pharma, which is a leading dermatology research company in Geneva, Switzerland. They are the first to release a cysteamine cream to treat hyperpigmentation. There are other cysteamine products on the market that do not have equivalent potency or efficacy to Cyspera.

How Does It Work?

This cream is made up two strong depigmenting molecules, stabilized cysteamine and isobionic amide. They work together to decrease more pathways in pigmentary disorders than other products on the market. Cysteamine hydrochloride is a metabolite of L-cysteine and a natural cellular component that is a first line alternative to hydroquinone. And Isobionic amide is a stronger version of niacinamide that works to further depigment other melanin pathways. While cysteamine is known to have a strong odor, Scientis Pharma uses new technology in the formulation to help decrease this smell while still maintaining the high percentage of cysteamine and increase efficacy.

Cysteamine is naturally present in our skin cells and also in breast milk. Regulating melanin production in the skin, it removes pigmented brown and dark spots while providing an even skin complexion. Cyspera can be applied to any skin type, any time of day and year, and maybe use on the face, neck, underarms, and body.

Benefits of Cyspera

It is the first and only topical cream to contain 7% stabilized cysteamine hydrochloride (HCI), which is formulated to significantly decrease the appearance of skin discoloration. Other formulations of cysteamine are not as effective.

Key benefits include:

  • Effective in improving the appearance of brown patches and dark spots.
  • Decreases the chance of skin discoloration reoccurring by using a maintenance phase of the cream.
  • Well tolerated for long term use.
  • It does not contain any hydroquinone.

Studies have shown:

  • Proven to decrease melanin pigment by 77% in hyperpigmented areas.
  • 90% of users notice a moderate to significant improvement in their skin

How Do You Apply Cysteamine?

Cysteamine is not a photosensitizer, which means it can be applied at any time regardless of sun intensity. It works with any skin phototype/ skin color/ ethnic background. However, sunscreen still needs to be applied year-round after application. There are two different phases and this will affect the number of applications you do each week.

  • Intense Phase – During this phase, the product will be applied once per day for 16 weeks, morning or evening, when it works into your daily routine.
  • Maintenance Phase – Once you hit your maintenance phase, you will only need to apply your cream once a day only two times per week. Changes can be seen in as little as 4 weeks, however Optimal results are typically seen around 8 to 12 weeks of use.

Application steps?

  • Apply 1 pump of the cream to dry, non-washed skin for 15 minutes (do not wash your face beforehand). If you have recently washed your face, then you will need to wait an hour for your application. You may feel a warming sensation or mild tingling for up to 30 minutes. Make sure the pump is primed so that product is released from both chambers…this may take 5 or more pumps to prime.
  • After 15 minutes, Remove the cream by applying 2 pumps of the neutralizer, which is a foaming facial cleanser, then rinse with water. Pat dry.
  • Lastly, apply the boost just as you would a moisturizer, and continue with the remainder of your skincare routine afterwards.

What else is in Cyspera?

  • Vitamin C (antioxidant, hydrates and brightens)
  • Vitamin E (antioxidant and skin barrier protection)
  • Isobionic Amide (a stronger version of niacinamide and a strong depigmenting molecule).
  • Lactobionic acid (improves cellular turnover and increases production of collegen and elastin)
  • Glycolic acid (exfoliates and boost collagen production)
  • Retinol/ Vitamin A derivative (increases cellular turnover, very small percentage which is not photo-sensitive)

Is Cysteamine Safe?

Cysteamine is safe, as it is naturally found within the human body. This cream is hydroquinone-free, corticosteroid-free, and paraben-free. It is an anti-carcinogenic and an anti-mutagenic agent. There have been numerous studies done on Cyspera and the effectiveness that it has on pigmentation disorders is significant.

Is Cysteamine well tolerated?

Yes…but every person is different. Read below to ensure the best outcome for your treatment.

Possible Local side effects could include:

  • Warming, tingling sensation, redness that should clear up in 30 minutes.
  • Possible irritation/ redness upon first usage of the product which should dissipate
  • Possible dryness which can be treated with moisturizer and should dissipate


  • To reduce the possibility of irritation, it is recommended to pause other topical products that are irritating for the first 10 days of using Cyspera. After the skin is acclimated to Cyspera, these products can be re-introduced.
  • For someone with very sensitive skin, or if the product is being used on areas that may be sensitive such as under eyes, eyelids, lips, etc, start with five minutes on the first day instead of 15, and then work up the time over the course of a week to the full 15 minutes.
  • Wait about a week after procedures that may be irritating to start/ continue Cyspera (laser/ peel/ micro needling).
  • Do not apply Cyspera to open sores, cuts or wounds or redness from flares of certain skin conditions such as rosacea. Always wait till any redness or irritation has dissipated to use Cyspera.

Who Should Not Use Cyspera Cream?

-No studies have been performed on women who are pregnant or breast-feeding, so it is advised not to use this product during those times.

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